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The concomitant utilization of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors might result in an increase in methadone plasma concentrations, which could bring about potentially fatal respiratory despair. Furthermore, discontinuation of concomitantly made use of cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may additiona

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